Research Highlight - An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO-) in the Alzheimer's Disease Brain
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Last updated 23 mai 2024
Peroxynitrite (ONOO-) plays a critical role in Alzheimer's disease (AD), and the association between ONOO- and AD is inexplicit. To reveal the ONOO- influxes in AD brains, an activatable activity-based fluorescence probe Rd-DPA3 was rationally designed by a structure-modulated strategy. Taking advantage of ONOO--sparked two-step cascade reactions of a novel chemical trigger, Rd-DPA3 specifica
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Small-molecule fluorescence-based probes for interrogating major
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Activity-based fluorescence probes for pathophysiological
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