0.2 Five subcategories of Autotransporter proteins . The unfolded
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Last updated 29 mai 2024
Download scientific diagram | 0.2 Five subcategories of Autotransporter proteins . The unfolded autotransporter of the T5SS is transferred to the periplasm by the SecYEG translocon, where several chaperones stabilize its unfolded structure. In the next stage, the translocator domain is inserted into the OM with the assistance of BamA, where it folds into a β-barrel. The unfolded passenger domain passes through the pore created by the translocator domain and folds into a β-helical structure. Structures and topology of the different type V secretion systems. The translocation domain is displayed in green, linker/Tps regions in purple, and passenger domains in blue. POTRA domains are labelled (P). The Type Va autotransporter model. The C-terminal membrane anchor (green) is recognized by the POTRA (P) domains of BamA; the Bam complex aids in inserting the β-barrel membrane anchor into the outer membrane (OM). The linker region (purple) then forms a hairpin inside the pore of the barrel. The passenger domain (blue) is pulled through the pore. The energy for this presumably derives from the sequential folding of the passenger domain on the outside of the cell. Once the passenger domain has been secreted, the linker assumes an α-helical conformation and plugs the pore. Type Vb autotransporter model. Vb subcategory are members of the two-partner secretion system (TPS) in which the passenger and the translocator domain harboring polypeptide-transport-associated (POTRA) motifs. The translocation proteins are known as TpsA and TpsB (green), and most of them are encoded in an operon. After their translocation through the inner membrane, TpsB forms the translocation β-barrel, which mediates secretion of the passenger protein (TpsA) through the outer membrane. Type Vc autotransporter model. Characterized by the presence of three passenger domains fused to the one-third segment of a fully functional C-terminal translocator domain allowing secretion of trimeric polypeptides. The Bam complex is required for trimeric autotransporter biogenesis and recognizes the C-terminal membrane anchor (purple). The Bam complex assists in trimerization of the β-barrel and membrane insertion. The linker regions (blue) form hairpins within the pore, and this leads to translocation of the polypeptides encoding the passenger domain. Type Vd autotransporter model. Autotransporters in this subcategory resemble a fusion between the Va, monomeric ATs, and the Vb, two partner system autotransporters. The passenger domain of PlpD (lipolytic enzyme) is connected to the translocator β-barrel with a POTRA domain and then is released by an autocatalytic reaction after translocation. Type Ve autotransporter model. Ve has an inverted topology with the passenger domain located in the C-terminal and the translocation unit in the N-terminal of the molecule; hence the term inverse autotransporter. Likewise, classical ATs, Ve are transported into the periplasm by the Sec translocon, assisted through the periplasm by common chaperones like SurA, and lastly, inserted into the outer membrane via the BAM complex from publication: Secretion Systems of Pathogenic Escherichia coli | Protein secretion plays a central role in modulating the interactions of bacteria with their environments. Bacterial ribosomes synthesize up to 8000 different proteins. Almost half of these become integrated in membranes and are secreted to the periplasm or to the external | Protein Secretion, Secretion and Bodily Secretions | ResearchGate, the professional network for scientists.
Heterogeneity in Protein Folding and Unfolding Reactions
Toxins, Free Full-Text
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria - ScienceDirect
BamA and BamD are essential for the secretion of trimeric autotransporter adhesins
Type V Protein Secretion Pathway: the Autotransporter Story
Molecular basis for the folding of β-helical autotransporter passenger domains. - Abstract - Europe PMC
Trimeric autotransporter adhesin - Wikipedia
Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter
Molecular optimization of autotransporter-based tyrosinase surface display - ScienceDirect
The Translocation Domain in Trimeric Autotransporter Adhesins Is Necessary and Sufficient for Trimerization and Autotransportation
Type V Protein Secretion Pathway: the Autotransporter Story
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