Conversion of •NO and ONOO − . Activated macrophages simultaneously

Download scientific diagram | Conversion of •NO and ONOO − . Activated macrophages simultaneously produce O 2 • − and •NO. ONOO − is largely protonated to ONOOH (pKa = 6.8) at physiological pH and is spontaneously isomerized to nitrate. During the isomerization, deleterious radical species, •OH and •NO 2 , are produced in lipophilic environments. Cells have protective systems, glutathione peroxidase (GPX) and peroxiredoxin (PRDX), that reduce ONOO − to nitrite, in GSH-and thioredoxin (TRX)-dependent manners, respectively. The reaction of ONOO − with CO 2 produces either CO 3 • -+ •NO 2 , which also have antimicrobial effects, or CO 2 + NO 3 -. from publication: Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling | When the expression of NOS2 in M1-polarized macrophages is induced, huge amounts of nitric oxide (•NO) are produced from arginine and molecular oxygen as the substrates. While anti-microbial action is the primary function of M1 macrophages, excessive activation may result in | Polyamines, Metabolics and Urea | ResearchGate, the professional network for scientists.

H2 Inhibits the Formation of Neutrophil Extracellular Traps

Reactive oxygen nanobiocatalysts: activity-mechanism disclosures, catalytic center evolutions, and changing states - Chemical Society Reviews (RSC Publishing) DOI:10.1039/D3CS00087G

Nitric oxide regulates multiple functions and fate of adult progenitor and stem cells

Macrophages: The Potent Immunoregulatory Innate Immune Cells

Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications - Andrabi - 2023 - Advanced Science - Wiley Online Library

Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments

Biochemical regulatory processes in the control of oxidants and antioxidants production in the brain of rats with iron and copper chronic overloads

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation - ScienceDirect

Molecules, Free Full-Text

The Complex Interplay between Antioxidants and ROS in Cancer: Trends in Cell Biology

Molecules, Free Full-Text

Engineering of Reversible Luminescent Probes for Real-Time Intravital Imaging of Liver Injury and Repair

Reactive Oxygen Species Generation in Neutrophils: Modulation by Nitric Oxide

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages